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Flupentixol dihydrochloride in daily doses of up to 3 mg possesses antidepressant, anxiolytic and activating properties which have been shown in many controlled, clinical trials. Its effect can be seen promptly ie, during the 1st week of treatment and also ceases soon after discontinuation.
Pharmacokinetics: The bioavailability after oral administration of flupentixol is about 40%. Maximum serum concentration is reached in 3-6 hrs. Flupentixol in small amounts crosses the placental barrier and is excreted in small amounts into the breast milk. The metabolites are devoid of psychopharmacological activity. The excretion proceeds mainly with feces but also to some degree with the urine. The biological half-life is about 35 hrs.
